Over The Counter Meds For Anxious Dogs. Among all, benadryl is the best medication to calm a hyper dog. Over the counter tranquilizing medication for dogs.

For under $15, you can find a variety of calming treats of various flavors for your dog. Here are the most commonly prescribed medications used to treat dog anxiety. To fireworks or thunderstorms) or if he is hyperactive, you can administer drugs based on melatonin.